Oral Treatment for Signs and Symptoms of Rheumatoid and Osteoarthritis
COXANTO™ (oxaprozin) capsules are indicated for the relief of signs and symptoms of Osteoarthritis, Rheumatoid Arthritis and Juvenile Rheumatoid Arthritis.
Learn More
† This page is intended for US healthcare professionals only.
ABOUT COXANTO™(OXAPROZIN) 300MG
FDA Approved Oral Treatment
COXANTO™ (oxaprozin) 300mg is a prescription-strength nonsteroidal anti-inflammatory drug (NSAID) indicated for the relief of signs and symptoms of Osteoarthritis, Rheumatoid Arthritis, and Juvenile Rheumatoid Arthritis. It works by blocking the COX-1 and COX-2 enzymes that produce prostaglandinschemicals responsible for pain, swelling, and stiffness. By reducing prostaglandin levels, COXANTO (oxaprozin) helps relive joint pain and stiffness, decrease swelling, and improve flexibility in patients living with these forms of arthritis.
Prescription Savings
Eligible commercially insured patients
may pay as little as $0* for COXANTO™ (oxaprozin)
300mg prescription.
How It Works
COXANTO™ (oxaprozin) inhibits the COX-1 and COX-2 enzyme, reducing the production of prostaglandins responsible for pain and inflammation
PATIENT SAVINGS
Patients pay as little as $0* for COXANTO™ (oxaprozin) 300mg
The SolaLOYALTY® Savings Program offers eligible patients up to $600 per prescription — with a maximum of $100 per bottle (up to 6 bottles).
- No patient registration is required to use the card
- The savings card can be applied to initial prescriptions and refills.
✔ Simply present to your pharmacist
✔ Maximum benefit of $600 per prescription.
How it Works
COXANTO™ (oxaprozin) 300mg works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are responsible for the conversion of arachidonic acid to prostaglandins. Prostaglandins are lipid compounds that play key roles in inflammation, pain sensitization, and fever regulation. By reducing prostaglandin synthesis, COXANTO™ (oxaprozin) exerts anti-inflammatory, analgesic, and antipyretic effects.
Additional Medical Information; Rx only
IMPORTANT SAFETY INFORMATION
WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS
Cardiovascular Thrombotic Events
-
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use.
- COXANTO is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.
Gastrointestinal Bleeding, Ulceration, and Perforation
-
NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.
CONTRAINDICATIONS
-
Known hypersensitivity to oxaprozin or any components of the drug product
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- In the setting of CABG surgery.
WARNINGS AND PRECAUTIONS
- Hepatotoxicity: Inform patients of warning signs and symptoms of hepatotoxicity. Discontinue if abnormal liver tests persist or worsen or if clinical signs and symptoms of liver disease develop
- Hypertension: Patients taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs. Monitor blood pressure
- Heart Failure and Edema: Avoid use of COXANTO in patients with severe heart failure unless benefits are expected to outweigh risk of worsening heart failure
- Renal Toxicity: Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia. Avoid use of COXANTO in patients with advanced renal disease unless benefits are expected to outweigh risk of worsening renal function
- Anaphylactic Reactions: Seek emergency help if an anaphylactic reaction occurs
- Exacerbation of Asthma Related to Aspirin Sensitivity: COXANTO is contraindicated in patients with aspirin-sensitive asthma. Monitor patients with preexisting asthma (without aspirin sensitivity)
- Serious Skin Reactions: Discontinue COXANTO at first appearance of skin rash or other signs of hypersensitivity
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Discontinue and evaluate clinically
- Fetal Toxicity: Limit use of NSAIDs, including COXANTO, between about 20 to 30 weeks in pregnancy due to the risk of oligohydramnios/fetal renal dysfunction. Avoid use of NSAIDs in women at about 30 weeks gestation and later in pregnancy due to the risks of oligohydramnios/fetal renal dysfunction and premature closure of the fetal ductus arteriosus
- Hematologic Toxicity: Monitor hemoglobin or hematocrit in patients with any signs or symptoms of anemia
ADVERSE REACTIONS
Most common adverse reactions (incidence > 3%) are: constipation, diarrhea, dyspepsia, nausea, rash
DRUG INTERACTIONS
- Drugs that Interfere with Hemostasis (e.g., warfarin, aspirin, selective serotonin reuptake inhibitors [SSRIs]/serotonin norepinephrine reuptake inhibitors [SNRIs]): Monitor patients for bleeding who are concomitantly taking COXANTO with drugs that interfere with hemostasis. Concomitant use of COXANTO and analgesic doses of aspirin is not generally recommended
- Angiotensin Converting Enzyme (ACE) Inhibitors, Angiotensin Receptor Blockers (ARB), or Beta- Blockers: Concomitant use with COXANTO may diminish the antihypertensive effect of these drugs. Monitor blood pressure
- ACE Inhibitors and ARBs: Concomitant use with COXANTO in elderly, volume depleted, or those with renal impairment may result in deterioration of renal function. In such high risk patients, monitor for signs of worsening renal function
- Diuretics: NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics. Monitor patients to assure diuretic efficacy including antihypertensive effects
- Digoxin: Concomitant use with COXANTO can increase serum concentration and prolong half-life of digoxin. Monitor serum digoxin levels
USE IN SPECIFIC POPULATIONS
- Infertility: NSAIDs are associated with reversible infertility. Consider withdrawal of COXANTO in women who have difficulties conceiving
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.